New Cure for 4-Hour Erections?

All Legal Rights Reserved.

. Erections lasting more time thanfour hours cut offthe supply of

fresh blood to the penis. Your bad

news is that it truly is very rarely used. As the consequence, it's an extremely

expensive "orphan drug" produced together with government assistance.

"This will take a while to have to the stage of your treatment," Juneja


Xia and colleagues statement their particular findings within the Oct. It's certainly not a

joke -- it's truly a healthcare emergency.

Swelling through priapism can be exquisitely painful. more than40% regarding men with sickle-cell anemia suffer priapism.

It additionally strikes a quantity of men with diabetes and may be a complication regarding erectile

dysfunction drugs -- especially those injected in to be able to the penis. The Actual result: Penile fibrosis , the actual formation involving scar

tissue in the primary body with the penis.

Men suffering penis pain along with damage from erections lasting

longer than four hours could take benefit of an orphan drug used to treat severe

"bubble boy" immune deficiency, mouse studies suggest.

The Actual condition, known as priapism , seems funny simply to people who have never

suffered it. but that isn't the actual worst

of it. "When we treated your mice, we do

not go to become able to whichever unwanted effects or any abnormality. We

can swiftly appropriate the actual priapism along with stop as well as treat penile fibrosis."

Present treatments

for priapism aren't optimal, says Harinder Juneja, MD, the College of

Texas hematologist whom treats many patients together with sickle-cell disease.

In case drug injections can't tighten the muscle mass which controls blood flow for you to the

penis, the excess blood should be withdrawn in the major body in the penis. Actually, the particular mice look better. Whilst studying mice lacking the actual gene that will malfunctions

in kids with severe mixed immune deficiency (SCID), Yang Xia, MD, PhD, and

colleagues at the University Or College involving Texas, Houston, noticed the mice suffered

priapism as well as penile fibrosis.

Replacing the actual enzyme created from the gene -- adenosine deaminase -- not necessarily only

relieved priapism, nevertheless markedly reduced the animals' penile fibrosis.

"We identified a new application to treat priapism having a drug that is

commonly accustomed to treat SCID," Xia tells WebMD. the good news is

that the actual treatment, PEG-ADA, is identified being safe within humans. Aside from becoming painful, these

treatments usually don't avoid penile fibrosis.

Today Xia along with colleagues get found out that priapism and penile fibrosis result

from excessive numbers of adenosine inside the blood.

"The discovery associated with excessive adenosine as the causative aspect with regard to both

prolonged penile erection as well as penile fibrosis in mice opens up the actual possibility

of treating and also preventing this painful and dangerous disorder," they


Juneja says he's wanting to get a clinical trial beneath way. This usually means permanent erectile


perhaps not really any more. all rights reserved

2009 WebMD, LLC.. To

do this, doctors might withdraw the blood with a needle or even surgically install a

shunt for you to divert blood flow from the penis. 26 issue of The

FASEB Journal.

By Daniel DeNoon

Reviewed through Louise Chang

2005-2008 WebMD, LLC


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